Publications

6.Xu, H., Delling, M., Jun, JC, and Clapham, DE (2006) Oregano, Thyme, and Clove-derived Flavors and Skin Sensitizers Activate Specific TRP Channels. Nature Neuroscience 2006 May; 9(5):628-635. Epub 2006 Apr 16.PDF

7. Xu, H.*, Blair, NT.*, and Clapham, DE. (2005) Camphor Activates and Strongly Desensitizes TRPV1 in a Vanilloid-independent Mechanism. The Journal of Neuroscience 2005; 25(39): 8924-37. PDF. The work was highlighted in The Journal of Neuroscience, 2005 Sep 28; 25(39), Nature, 2005 Oct 13; 437: 930-931, and Nature Reviews Neuroscience, 2005, 6: 826.

8. Zhuang, ZY., Xu, H., Clapham, DE., and Ji, RR.(2004) Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. The Journal of Neuroscience 2004; 24(38):8300-9. PDF

9. Ito, M.*, Xu, H.*, Guffanti, A., Wei, Y., Zvi, L., Clapham, DE., and Krulwich, TA.(2004) The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis and pH homeostasis of an alkaliphilic Bacillus. Proceedings of the National Academy of Sciences (USA) 2004; 101(29): 10566-71. Epub 2004 Jul 08. PDF

10. Moran, MM., Xu, H, and Clapham, DE. (2004) TRP ion channels in the nervous system. Current Opinion in Neurobiology 2004; 14(3): 362-9. PDF

11. Xu, H.*, Jin, J.*, DeFelice, LJ., Andrews, NC., and Clapham, DE. (2004) A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biology 2004 Mar;2(3):E50. Epub 2004 Mar 16. Synopsis can be found at PLoS Biol. 2004 Mar;2(3):E70. Epub 2004 Mar 16. PDF

12. Koishi, R.*, Xu, H.*, Ren D., Navarro B., Spiller BW., Shi Q., and Clapham, DE. (2004) A superfamily of voltage-gated sodium channels in bacteria. Journal of Biological Chemistry. 279(10):9532-8. Epub 2003 Dec 09. PDF

13. Xu, H.*, Ramsey, IS.*, Kotecha, SA.*, Moran, MM., Chong, JA., Curtis, R., DiStefano, PS., Silos-Santiago, I., Xie, Y., Lawson, D., Ge, P., Lilly, J., and Clapham, DE. (2002). TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature, 418, 181-186, published online 23 June 2002; doi:10.1038/nature00882. PDF Comments about this work and other groups' related articles see "Breakthrough of The Year" by Science, Vol 298, Issue 5602, 2297-2303, 20 December 2002.

14. Ren, D.*, Navarro, B.*, Xu, H.*, Yue, L.*, Shi, Q., and Clapham, DE. (2001). A prokaryotic voltage-gated sodium channel. Science, Dec 14 2001: 2372-2375. Perspectives about this paper can be found in Science, 294: 2306-2308.PDF

15. Wang, R., Rojas, A., Wu, J., Piao, H., Adams C. Y., Xu, H., Shi, Y. and Jiang, C. (2005) Determinant role of membrane helices in gating of intracellular ligand-gated ion channels. Journal of Membrane Biology, 204, 1-10.

16. Wu, J., Xu, H., Shen, W., and Jiang, C. (2004) Expression and coexpression CO2-sensitive Kir channels in brainstem neurons of rats. Journal of Membrane Biology, 197(3):179-91.

17. Cui, N. *, Wu, J. *, Xu, H. *, Wang, R., Rojas, A., Piao, H., Mao, J., Abdulkadir, L., Li, L., and Jiang, C. (2003) A threonine residues (Thr71) plays a critical role in the gating Kir6.2 channel by intracellular ATP and pH. Journal of Membrane Biology, 192, 111-122.

18. Wu, J., Xu, H., Yang, Z., Wang, Y., Mao, J., and Jiang, C (2002). Protons activate homomeric Kir6.2 channels by selective suppression of the long and intermediate closures. Journal of Membrane Biology, 190, 105-116.

19. Wu, J., Cui, N., Piao, H., Wang, Y., Xu, H., Mao, J., and Jiang, C. (2002). Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP. Journal of Physiology (London). 543, 495-505.

20. Xu, H., Wu, J., Cui, N., Abdulkadir, L., Wang, R., Mao, J., Giwa, LR., Chanchevalap, S., and Jiang, C. (2001). Distinct histidine residues control the acid-induced activation and inhibition of the cloned KATP channel. Journal of Biological Chemistry, 276, 38690-38696.

21. Jiang, C., Xu, H., Cui, N., and Wu, J. (2001). An alternative approach to the identification of respiratory central chemoreceptors in the brainstem. Respiratory Physiology, 2001 Dec;129(1-2):141-157.

22. Piao, H., Cui, N., Xu, H., Mao, J., Rojas, A., Wang, R., Abdulkadir, L., Li, L., Wu, J., and Jiang, C. (2001). Requirement of multiple protein domains and residues for gating KATP channels by intracellular pH. Journal of Biological Chemistry, 276, 36673-36680.

23. Cui, N., Giwa, LR., Xu, H., Abdulkadir, L., and Jiang, C. (2001). Modulation of the heteromeric Kir4.1-Kir5.1 channels by pCO2 at physiological levels, Journal of Cellular Physiology, 189, 229-236.

24. Jiang, C., Qu, Z., and Xu, H. (2001). Gating of inward rectifier K+ channels by proton-mediated interactions of internal protein domains. Trend in Cardiovascular Medicine, 12, 5-13.

25. Xu, H.*, Cui, N.*, Yang, Z., Wu, J., Giwa, LR., Abdulkadir, L., Sharma, P., and Jiang, C. (2001). Direct activation of KATP channels by intracellular acidosis. Journal of Biological Chemistry, 276, 12898-12902. * Co-first author.

26. Xu, H.*, Yang, Z.*, Cui, N., Valesky, WW., and Jiang, C. (2000). A single residue responsible for the difference of Kir4.1 channel from Kir1.1 in pH-sensitivity, rectification and single channel conductance. Journal of Physiology (London), 528.2, pp. 267-277.

27. Xu, H., Yang, Z., Cui, N., Giwa, LR., Abdulkadir, L., Patel, M., Sharma, P., Shan, G., Shen W., and Jiang C. (2000). Molecular determinants for the distinct pH sensitivity of Kir1.1 and Kir4.1. American Journal of Physiology (Cell) , 279: C1464-C1471.

28. Xu, H., Cui, N., Yang, Z., Qu, Z., and Jiang, C. (2000). Modulation of Kir4.1 and Kir5.1 by hypercapnia and intracellular acidosis. Journal of Physiology (London), 524, 725-735.

29. Yang, Z., Xu, H., Cui, N., Qu, Z., Chanchevalap, S., Shen, W., and Jiang, C. (2000). Biophysical and molecular mechanisms underlying the modulation of heteromeric Kir4.1-Kir5.1 channels by CO2 and pH. Journal of General Physiology 116: 33-46

30. Qu, Z., Yang, Z., Cui, N., Chanchevalap, S., Zhu, G., Liu, C., Xu, H., Shen, W., Wu, J., Li, Y., and Jiang, C. (2000) Kir gating by proton-mediated interactions of N- and C-terminal domains. Journal of Biological Chemistry, 275, 31573-31580.

31. Zhu, G., Liu, C., Chanchevalap, S., Xu, H., and Jiang, C. (2000) CO2 inhibits specific inward rectifier K+ channels by decreases in intra- and extracellular pH. Journal of Cellular Physiology, 183, 53-64.

32. Zhu, G., Zhang, Y., Xu, H. , and Jiang, C. (1998) Characterization of endogenous ionic currents of human embryonic kidney (HEK 293) cells, Journal of Neuroscience Methods. 81(1-2):73-83.

* Co-first author.