Publications

Ren G, Stephan D, Xu Z, Zheng Y, Tang D, Harrison RS, Kurz M, Jarrott R, Shouldice SR, Hiniker A, Martin JL, Heras B, Bardwell JC.. (2009) Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue. J Biol Chem. 284(15):10150-9. (Pubmed)

Tapley TL, Körner JL, Barge MT, Hupfeld J, Schauerte JA, Gafni A, Jakob U, Bardwell JC.. (2009) Structural plasticity of an acid-activated chaperone allows promiscuous substrate binding. Proc Natl Acad Sci U S A. 106(14):5557-62. (Pubmed)

Mamathambika BS, Bardwell JC. (2008) Disulfide-linked protein folding pathways. Annu Rev Cell Dev Biol. 24:211-35. Review. (Pubmed)

Pan JL, Sliskovic I, Bardwell JC.. (2008) Mutants in DsbB that appear to redirect oxidation through the disulfide isomerization pathway. J Mol Biol. 377(5):1433-42. (Pubmed)

Vertommen D, Depuydt M, Pan J, Leverrier P, Knoops L, Szikora JP, Messens J, Bardwell JC, Collet JF.. (2008) The disulphide isomerase DsbC cooperates with the oxidase DsbA in a DsbD-independent manner. Mol Microbiol. 67(2):336-49. (Pubmed)

Gleiter S, Bardwell JC.. (2008) Disulfide bond isomerization in prokaryotes. Biochim Biophys Acta. 1783(4):530-4. (Pubmed)

Masip L, Klein-Marcuschamer D, Quan S, Bardwel JC, Georgiou G. (2008) Laboratory evolution of Escherichia coli thioredoxin for enhanced catalysis of protein oxidation in the periplasm reveals a phylogenetically conserved substrate specificity determinant. . J Biol Chem. 283(2):840-8. (Pubmed)

Quan S, Schneider I, Pan J, Von Hacht A, Bardwell JC. (2007) The CXXC motif is more than a redox rheostat. J Biol Chem. 282(39):38823-33. (Pubmed)

Tapley TL, Eichner T, Gleiter S, Ballou DP, Bardwell JC. (2007) Kinetic characterization of the disulfide bond-forming enzyme DsbB. J Biol Chem. 282(14):10263-71. (Pubmed)

Hiniker A, Vertommen D, Bardwell JC, Collet JF. (2006) Evidence for Conformational Changes within DsbD: Possible Role for Membrane-Embedded Proline Residues. J. Bacteriol. Oct;188(20):7317-20. (Pubmed)

Pan JL, Bardwell JC. (2006) The origami of thioredoxin-like folds. Protein Sci. Oct;15(10):2217-27. (Pubmed)

Hiniker A, Collet JF, Bardwell JC. (2005) Copper stress causes an in vivo requirement for the Escherichia coli disulfide isomerase DsbC. J. Biol. Chem. Oct 7;280(40):33785-91. Epub 2005 Aug 8. (Pubmed)

Collet JF, Peisach D, Bardwell JC, Xu Z. (2005) The crystal structure of TrxA(CACA): Insights into the formation of a [2Fe-2S] iron-sulfur cluster in an Escherichia coli thioredoxin mutant. Protein Sci. Jul;14(7):1863-9. (Pubmed)

Collet, J-F. and Bardwell J.C.A. . (2005) The Catalysis of disulfide bond formation in Prokaryotes. In Protein Folding Handbook, Buchner/Kiefhaber Eds. Wiley-VCH.

Tan, J. Lu Y., and Bardwell J.C.A.. (2005) Mutational Anlysis of the disulfide catalysts DsbA and DsbB. J.Bacteriol. 187: 1504-10. (Pubmed)

Bardwell J.C.A.. (2005) The dance of disulfide formation. Nat. Struct. Mol. Biol. 11: 582-3. (Pubmed)

Bardwell J.C.A.. (2005) Thiol modifications in a snapshot. Nat. Biotechno. 23: 42-3. (Pubmed)

Nakamoto H, Bardwell JC.. (2004) Catalysis of disulfide bond formation and isomerization in the Escherichia coli periplasm. Biochim. Biophys. Acta. Nov 11;1694(1-3):111-9. (Pubmed)

Tan JT, Bardwell JC.. (2004) Key players involved in bacterial disulfide-bond formation. Chembiochem. Nov 5;5(11):1479-87. (Pubmed)

Hiniker A, Bardwell JC.. (2004) Disulfide relays between and within proteins: the Ero1p structure. Trends Biochem. Sci. Oct;29(10):516-9. (Pubmed)

Masip L, Pan JL, Haldar S, Penner-Hahn J, Georgiou G, Bardwell JC, and Collet Jean-Francois. (2004) An Engineered pathway for the formation of protein disulfide bonds. Science. 303:1185 - 1189. (Pubmed)

Hiniker A and Bardwell JC. (2004) in vivo substrate specificity of periplasmic disulfide oxidoreductases. J. Biol. Chem. Mar 26;279(13):12967-73. Epub 2004 Jan 15. (Pubmed)

Kadokura H., Tian H., Zander T., Bardwell J.C., and Beckwith J.. (2004) Snapshots of DsbA in Action: detection of proteins in the process of oxidative folding. Science. 303(5657):534-537.

Hiniker A. and Bardwell J.C.. (2004) in vivo substrate specificity of periplasmic disulfide oxidoreductases. J. Biol. Chem. 2004 Mar 26;279(13):12967-73. Epub 2004 Jan 15. (Pubmed)

Collet J-F. and Bardwell J.C.A.. (2003) Oxidative folding in Bacteria. NATO Science series.

Collet J.F., D'Souza J.C., Jakob U., Bardwell J.C.. (2003) Thioredoxin 2, an oxidative stress-induced protein, contains a high affinity zinc binding site. J. Biol. Chem. 278(46):45325-32. (Pubmed)

Regeimbal J., Gleiter, S., Trumpower, B.L., Yu, C.A., Diwakar, M., Ballou, D.P., and Bardwell, J.C.. (2003) Disulfide bond formation involves a quinhydrone-type charge-transfer complex. Proc. Nat. Acad. of Sci USA. 100(24):13779-84. (Pubmed)

Goulding CW, Apostol MI, Gleiter S, Parseghian A, Bardwell J, Gennaro M, and Eisenberg D. (2003) Gram-positive DsbE proteins function differently from gram-negative DsbE homologs: A structure function analysis of DsbE from Mycobacterium tuberculosis. J. Biol. Chem. 2004 Jan 30;279(5):3516-24. Epub 2003 Nov 3. (Pubmed)

Hiniker A. and Bardwell J.C.. (2003) Disulfide bond isomerization in prokaryotes. Biochemistry. Feb 11;42(5): 1179-85. (Pubmed)

Bardwell J.C.. (2002) Disulfide bond formation, a race between FAD and oxygen. Dev. Cell. Dec;3(6):758-60. (Pubmed)

Regeimbal J. and Bardwell J.C.. (2002) DsbB catalyzes disulfide bond formation de novo. J. Biol. Chem. Sep 6;277(36):32706-13. (Pubmed)

Collet J.F., Reimer J., Bader M.W., and Bardwell J.C.. (2002) Reconstitution of a disulfide isomerization system. J. Biol. Chem. Jul 26;277(30):26886-92. (Pubmed)

Tan J., Jakob U., and Bardwell J.C.. (2002) Overexpression of two different GTPases rescues a null mutation in a heat-induced rRNA. J. Bacteriol. May;184(10):2692-8. (Pubmed)

Collet J.F. and Bardwell J.C.. (2002) Oxidative protein folding in bacteria. Mol. Microbiol. Apr;44(1):1-8. (Pubmed)

Xie T, Yu L, Bader MW, Bardwell JC, and Yu CA. (2002) Identification of the ubiquinone-binding domain in the disulfide catalyst disulfide bond protein B. J. Biol. Chem. Jan 18;277(3):1649-52. (Pubmed)

Collet J.F. and Bardwell J.C.. (2002) Disulfides out of thin air. Nat. Struct. Biol. . Jan;9(1):2-3. (Pubmed)

Bader, MW and Bardwell JC. (2001) Catalysis of disulfide bond formation and isomerization in Escherichia coli. Adv. Protein Chem. 59:283-301. (Pubmed)

Goldstone D., Haebel P.W., Katzen F., Bader M.W., Bardwell J.C., Beckwith J., and Metcalf P. . (2001) DsbC activation by the N-terminal domain of DsbD. Proc. Natl. Acad. Sci. USA. . Aug 14;98(17):9551-6. (Pubmed)

Graumann J, Lilie H, Tang X, Tucker KA, Hoffman JH, Vijayalakshmi J, Saper M, Bardwell JC, and Jakob U. (2001) Activation of the redox-regulated molecular chaperone Hsp33-a two-step mechanism. Structure (Camb). May 9;9(5):377-87. (Pubmed)

Bader M.W., Hiniker A., Regeimbal J., Goldstone D., Haebel P.W., Riemer J., Metcalf P., and Bardwell J.C.. (2001) Turning a disulfide into an oxidase: DsbC mutants that imitate DsbA. EMBO J. Apr 2;20(7):1555-62. (Pubmed)

Bessette PH, Qiu J, Bardwell JC, Swartz JR, and Georgiou G. (2001) Effects of sequences of the active-site dipeptides of DsbA and DsbC on in vivo folding of multidisulfide protein in Escherichia coli. J. Bacteriol. Feb;183(3):980-8. (Pubmed)

Jakob U, Eser M, and Bardwell JC. (2000) Redox switch of hsp33 has a novel zinc-binding motif. J. Biol. Chem. Dec 8;275(34):38302-10. (Pubmed)

Kadokura H., Bader M., Tian H., Bardwell J.C., and Beckwith J. (2000) Roles of a conserved arginine residue of DsbB in linking protein disulfide-bond-formation pathway to the respiratory chain in Escherichia coli. Proc. Natl. Acad. Sci. USA. Sep 26;97(20):10884-9. (Pubmed)

Bader M.W., Xie T., Yu C.A., and Bardwell J.C.. (2000) Disulfide bonds are generated by quinone reduction. J Biol Chem. Aug 25;275(34):26082-8. (Pubmed)

Bugl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, and Jakob U. (2000) RNA methylation under heat shock control. Mol. Cell. Aug;6(2):349-60. (Pubmed)

Shao F., Bader M.W., Jakob U., and Bardwell J.C.. (2000) DsbG, a protein disulfide isomerase with chaperone activtity. J. Biol. Chem. May 5;275(18):13349-52. (Pubmed)

Wong C, Sridhara S, Bardwell JC, and Jakob U. (2000) Heating greatly speeds Coomassie blue staining and destaining. Biotechniques. Mar;28(3):426-28,430,432. (Pubmed)

Korber P., Stahl J.M., Nierhaus K.H., and Bardwell J.C.. (2000) Hsp15: a ribosome-associated heat shock protein. EMBO J. Feb 15;19(4):741-8. (Pubmed)

Staker BL, Korber P, Bardwell JC, and Saper MA.. (2000) Structure of Hsp15 reveals a novel RNA-binding motif. EMBO J. Feb 15;19(4):749-57. (Pubmed)

Bader M, Winther JR, and Bardwell JC. (1999) Protein oxidation: prime suspect found 'not guilty'. Nat Cell Biol. . Jul;1(3):E57-8. (Pubmed)

Bader M., Muse W., Ballou D.P., Gassner C., and Bardwell J.C.. (1999) Oxidative protein folding is driven by the electron transport chain. Cell. Jul 23;98(2):217-27. (Pubmed)

Jakob U., Muse W., Eser M., and Bardwell J.C.. (1999) Chaperone activity with a redox switch. Cell. Feb 5;96(3):341-52. (Pubmed)

Korber P., Zander T., Herschlag D., and Bardwell J.C.. (1999) A new heat shock protein that binds nucleic acids. J Biol Chem. Jan 1;274(1):249-56. (Pubmed)

Guddat LW, Bardwell JC, and Martin JL.. (1998) Crystal structures of reduced and oxidized DsbA: investigation of domain motion and thiolate stability. Structure. Jun 15;6(6):757-767. (Pubmed)

Bader M, Muse W, Zander T, and Bardwell J.. (1998) Reconstitution of a protein disulfide catalytic system. J Biol Chem. Apr 24;273(17):10302-7. (Pubmed)

Zander T, Phadke ND, and Bardwell JC. (1998) Disulfide bond catalysts in Escherichia coli. Methods Enzymol. 290:59-74. (Pubmed)

Guddat LW, Bardwell JC, Glockshuber R, Huber-Wunderlich M, Zander T, and Martin JL. (1997) Structural analysis of three His32 mutants of DsbA: support for an electrostatic role in His32 in DsbA stability. Protein Sci. Sep;6(9):1893-900. (Pubmed)

Guddat LW, Bardwell JC, Zander T, and Martin JL.. (1997) The uncharged surface features surrounding the active site of Escherichia coli DsbA are conserved and are implicated in peptide binding. Protein Sci. Jun;6(6):1148-56. (Pubmed)

Grauschopf U, Winther JR, Korber P, Zander T, Dallinger P, and Bardwell JC. (1995) Why is DsbA such an oxidizing disulfide catalyst?. Cell. Dec 15;83(6):947-55. (Pubmed)

Jakob U, Meyer I, Bugl H, Andre S, Bardwell JC, and Buchner J.. (1995) Structural organization of procaryotic and eucaryotic Hsp90. Influence of divalent cations on structure and function. J Biol Chem. Jun 16;270(24):14412-9. (Pubmed)

Bardwell JC.. (1994) Building bridges:disulphide bond formation in the cell. Mol Microbiol. Oct;14(2):199-205. (Pubmed)

Martin JL, Bardwell, and Kuriyan J.. (1993) Crystal structure of the DsbA protein required for disulphide bond formation in vivo. Nature. Sep 30;365(6445):464-8. (Pubmed)

Bardwell JC and Beckwith J.. (1993) The bonds that tie: catalyzed disulfide bond formation. Cell. Sep 10;74(5):769-71. (Pubmed)

Zapun A, Bardwell JC, and Creighton TE. (1993) The reactive and destabilizing disulfide bond of DsbA, a protein required for protein disulfide bond formation in vivo. Biochemistry. May 18;32(19):5082-92. (Pubmed)

Martin JL, Waksman G, Bardwell JC, Beckwith J, and Kuriyan J.. (1993) Crystallization of DsbA, an Escherichia coli protein required for disulphide bond formation in vivo. J Mol Biol. Apr 5;230(3):1097-100. (Pubmed)

Bardwell JC, Lee JO, Jander G, Martin N, Belin D, and Beckwith J.. (1993) A pathway for disulfide bond formation in vivo. Proc Natl Acad Sci USA. Feb 1;90(3):1038-42. (Pubmed)

Bardwell JC, McGovern K, and Beckwith J.. (1991) Identification of a protein required for disulfide bond formation in vivo. Cell. Nov 1;67(3):581-9. (Pubmed)

Yeung T, Mullin DA, Chen KS, Craig EA, Bardwell JC, and Walker JR. (1990) Sequence and expression of the Escherichia coli recR locus. J Bacteriol. Oct;172(10):6042-7. (Pubmed)

Chen SM, Takiff HE, Barber AM, Dubois GC, Bardwell JC, and Court DL.. (1990) Expression and characterization of RNase III and Era proteins. Products of the rnc operon of Escherichia coli. J Biol Chem. Feb 15;265(5):2888-95. (Pubmed)

Bardwell JC, Regnier P, Chem SM, Nakamura Y, Grunberg-Manago M, Court DL.. (1989) Autoregulation of RNase III operon by mRNA processing. EMBO J. Nov;8(11):3401-7. (Pubmed)

Bardwell JC and Craig EA. (1988) Ancient heat shock gene is dispensable. J Bacteriol. Jul;170(7):2977-83. (Pubmed)

Bardwell JC and Craig EA.. (1987) Eukaryotic Mr 83,000 heat shock protein has a homologue in Escherichia coli. Proc Natl Acad Sci USA. Aug;84(15):5177-81. (Pubmed)

Bardwell JC, Tilly K, Craig E, King J, Zylicz M, and Georgopoulos C.. (1986) The nucleotide sequence of the Escherichia coli K12 dnaJ+ gene.  A gene that encodes a heat shock protein. J Biol Chem. Feb 5;261(4):1782-5. (Pubmed)

Cowing DW, Bardwell JC, Craig EA, Woolford C, Hendrix RW, and Gross CA. (1985) Consensus sequence for Escherichia coli heat shock gene promoters. Proc Natl Acad Sci USA. May;82(9):2679-83. (Pubmed)

Bardwell JC and Craig EA.. (1984) Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous. Proc Natl Acad Sci USA. Feb;81(3):848-52. (Pubmed)