Assistant Professor Matthew Chapman and his lab group offer
novel insights into how bacteria form fibers called curli, giving intriguing clues to the formation of harmful protein tangles in devastating diseases involving aberrant protein folding.
Chapman and his lab group have been exploring bacterial amyloids, using an approach that blends microscopy, biochemistry, and genetics.
In the current work, the researchers reveal details of how curli—functional amyloid fibers assembled by
E. coli and certain other bacteria—are assembled.
