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| Motif Search | Advanced Motif Search | Protein Info | About CoSMoS | CoSMoS Help |
CoSMoS is a database of alignments of all Escherichia coli proteins with their homologues in 2780 different species found in the NCBI RefSeq (release 9) database. CoSMoS motif search can be searched for sequence motifs in all proteins encoded in the E. coli genome and displays information on their evolutionary conservation.
The user can specify in the advanced search mode, which part of the motif should be used in the calculation of the evolutionary conservation and which parts should be displayed.
CoSMoS protein info pages provide useful information about the conservation of every individual amino acid in a protein at a glance.
The underlying alignment data can be further examined by following the links in the result pages of the sequence motif search or the protein info pages.
CoSMoS was developed by Lars I Leichert, Xiao Liu and Neeraj Korde in the Lab of Ursula Jakob at the University of Michigan.
For more information about CoSMoS, please read the help section or contact us.
CoSMoS: Conserved Sequence Motif Search in the proteome.
Liu, X.I., Korde, N., Jakob, U. and L.I. Leichert. 2006.
BMC Bioinformatics 7(1): 37 (Abstract)
Lars I Leichert
The University of Michigan
Dept. of Molecular, Cellular and Developmental Biology
830 N. University
Ann Arbor, MI 48109-1048
E-Mail: leichert@umich.edu
Fax: +1 734 647 0884